Electrochemical, invivo and invitro study of Acyclovir and Co(II) Complex
نویسندگان
چکیده
The antibiotic drug 2-amino-1,9-dihydro-9-(2-hydroxyethoxy)methyl)-6H-purin-6-one has been quantitatively and qualitatively analysis by polarographic & amperometric process. Acyclovir give well identified wave in 1.0mkcl at pH5.0±0.2.Co (II)-Acyclovir complex studied in aqueous phase..The IR spectral data on the drug & its Co (II) complex indicate the co-ordination through nitrogen atom of azid group. The data showed a shift bands of azide group in complex from1634 cm -1 1651-cm -1 .Hence the tentative structure of the complex has been suggested. The antibiotic activity of the complex has been determine by using paper disc method against Streptococcus A ,K. Pneumonia, Salmonella. Typhi, and Aspergillus. A ,etc .Looking at this inhabitation power against the different test pathogens..It presumed that the complex may be more potent at compare to the parent drug .Pharmacological study shows the toxicological or non toxicological study of complex drugs
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